T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations.

ABSTRACT:

Background

T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce.

Objective

To describe longitudinal changes in T1-w/T2-w in patients with clinically isolated syndrome (CIS) and multiple sclerosis, and to investigate their clinical associations.

Methods

T1-w/T2-w images were generated and the mean value obtained in the corresponding lesion, normal-appearing grey (NAGM) and white matter (NAWM) masks. By co-registering baseline to follow-up MRI, evolved lesions were assessed; and by placing the mask of new lesions to the baseline study, the pre-lesional tissue integrity

SUBMITTER: Boaventura M 

PROVIDER: S-EPMC8866895 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature