Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial.

ABSTRACT:

Purpose

Retinal microvascular endothelial dysfunction is thought to be of importance in the development of ocular vascular diseases. Obstructive sleep apnoea (OSA) causes macrovascular endothelial dysfunction, but the effect of OSA on retinal microvascular endothelial function is not known. We aimed to determine the effect of OSA on retinal microvascular function.

Methods

We conducted a multi-centre, double-blind, randomised, parallel, controlled trial in patients with known moderate-to-severe OSA, established on continuous positive airway pressure (CPAP). Participants were randomised to 14 nights of either continued CPAP or sham CPAP to generate a return of OSA. Retinal vascular responses to flickering light were measured using dynamic vessel analysis both at baseline and a

SUBMITTER: Turnbull CD 

PROVIDER: S-EPMC8866916 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature