Microstructure-Weighted Connectomics in Multiple Sclerosis.

ABSTRACT: Introduction: Graph theory has been applied to study the pathophysiology of multiple sclerosis (MS) since it provides global and focal measures of brain network properties that are affected by MS. Typically, the connection strength and, consequently, the network properties are computed by counting the number of streamlines (NOS) connecting couples of gray matter regions. However, recent studies have shown that this method is not quantitative. Methods: We evaluated diffusion-based microstructural measures extracted from three different models to assess the network properties in a group of 66 MS patients and 64 healthy subjects. Besides, we assessed their correlation with patients' disability and with a biological measure of neuroaxonal damage. Results:<

SUBMITTER: Bosticardo S 

PROVIDER: S-EPMC8867108 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature