Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates.

ABSTRACT: A key behavior observed during morphogenesis, wound healing, and cancer invasion is that of collective and coordinated cellular motion. Hence, understanding the different aspects of such coordinated migration is fundamental for describing and treating cancer and other pathological defects. In general, individual cells exert forces on their environment in order to move, and collective motion is coordinated by cell-cell adhesion-based forces. However, this notion ignores other mechanisms that encourage cellular movement, such as pressure differences. Here, using model tumors, it is found that increased pressure drove coordinated cellular motion independent of cell-cell adhesion by triggering cell swelling in a soft extracellular matrix (ECM). In the resulting phenotype, a rapid burst-like st

SUBMITTER: Raghuraman S 

PROVIDER: S-EPMC8867140 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature