Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation.

ABSTRACT: Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing technologies such as optogenetics and chemogenetics require the introduction of foreign proteins, which adds a layer of complication and hinders their clinical translation. A novel technique, magnetomechanical stimulation (MMS), that enables remote and selective control of astrocytes without genetic modification is described here. MMS exploits the mechanosensitivity of astrocytes and triggers mechanogated Ca²⁺ and adenosine triphosphate (ATP) signaling by applying a magnetic field to antibody-functionalized magnetic particles that are target

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8867145 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature