Hormonal Therapy for Infantile Spasms: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

The limitations of adrenocorticotrophic hormone (ACTH) treatment for infantile spasms (ISs), such as high costs, limited availability, and adverse effects (AEs), make it necessary to explore whether corticosteroids are optimal alternatives. Many other compelling treatments have gone through trials due to the suboptimal effectiveness of hormonal therapy. A systematic review and meta-analysis were performed to evaluate the effectiveness and safety of hormonal therapy for patients with ISs.

Methods

EMBASE, Ovid MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and online registers were searched through April 2021 for randomized controlled trials (RCTs).

Results

A total of 19 RCTs (N = 1,279) were included. There was no significant differ

SUBMITTER: Guang S 

PROVIDER: S-EPMC8867209 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature