Analysis of eGFR index category and annual eGFR slope association with adverse clinical outcomes using real-world Japanese data: a retrospective database study.

ABSTRACT:

Objectives

Real-world clinical outcome data of patients with an above-normal estimated glomerular filtration rate (eGFR) and increasing eGFR over time (eGFR slope) are scarce. Although eGFR is commonly recorded, eGFR slopes are rarely used for adverse outcome risk categorisation in clinical practice. We investigated the association of above-normal/below-normal eGFR ranges and increasing/declining eGFR slopes with clinical outcomes in Japan.

Design

Observational cohort study.

Setting

Primary and acute care hospitals; 423 centres.

Participants

57 452 patients aged ≥16 years with ≥3 eGFR values (latest available January 2013-December 2016) from the Japanese Medical Data Vision database were stratified into six index eGFR and six eGFR slope groups (slopes calculate

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8867325 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature