Implications of Satellitosis or In-transit Metastasis in Cutaneous Squamous Cell Carcinoma: A Prognostic Omission in Cancer Staging Systems.

ABSTRACT:

Importance

Unlike Merkel cell carcinoma and melanoma, satellitosis or in-transit metastasis (S-ITM) is not incorporated into the current cutaneous squamous cell carcinoma (CSCC) staging systems. It is important to determine if the clinical outcomes of S-ITM are relevant to prognosis for patients with CSCC.

Objectives

To evaluate the association of S-ITM with clinical outcomes in patients with CSCC and to determine its prognostic implications.

Design, settings, and participants

A dual-institution (Cleveland Clinic and Brigham and Women's Hospital) database was queried for patients who were treated for CSCC in 2010 to 2020. Patients who were node-negative and had S-ITM-the presence of dermal lesions between the primary tumor and first-echelon lymphatic nodal basins at a

SUBMITTER: Smile TD 

PROVIDER: S-EPMC8867391 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature