The dynamicity of acute ozone-induced systemic leukocyte trafficking and adrenal-derived stress hormones.

ABSTRACT: Ozone exposure induces neuroendocrine stress response, which causes lymphopenia. It was hypothesized that ozone-induced increases in stress hormones will temporally follow changes in circulating granulocytes, monocytes- and lymphocyte subpopulations. The goal of this study was to chronicle the changes in circulating stress hormones, cytokines, and leukocyte trafficking during 4 h exposure to ozone. Male Wistar Kyoto rats were exposed to air or ozone (0.4 or 0.8 ppm) for 0.5, 1, 2, or 4 h. After each time point, circulating stress hormones, cytokines, and lung gene expression were assessed along with live and apoptotic granulocytes, monocytes (classical and non-classical), and lymphocytes (B, T_h, and T_c) in blood, thymus, and spleen using flow cytometry. Circulating st

SUBMITTER: Henriquez AR 

PROVIDER: S-EPMC8867491 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature