Hippocampal acidity and volume are differentially associated with spatial navigation in older adults.

ABSTRACT: The hippocampus is negatively affected by aging and is critical for spatial navigation. While there is evidence that wayfinding navigation tasks are especially sensitive to preclinical hippocampal deterioration, these studies have primarily used volumetric hippocampal imaging without considering microstructural properties or anatomical variation within the hippocampus. T1ρ is an MRI measure sensitive to regional pH, with longer relaxation rates reflecting acidosis as a marker of metabolic dysfunction and neuropathological burden. For the first time, we investigate how measures of wayfinding including landmark location learning and delayed memory in cognitively normal older adults (N = 84) relate to both hippocampal volume and T1ρ in the anterior and posterior hippocampus. Regression analys

SUBMITTER: Sodoma MJ 

PROVIDER: S-EPMC8867536 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature