Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents.

ABSTRACT: Boron nanoparticles (BNPs), functionalized with hydroxyl groups, were synthesized in situ by a cascade process, followed by bromination and hydrolyzation reactions. These functionalized BNPs, (B _m (OH) _n ), were characterized using ¹H and ¹¹B NMR spectra, Fourier-transform infrared (FT-IR) spectroscopy, inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS) methods. These nanoparticles were also evaluated in vitro for their antimalarial activity against Plasmodium falciparum (3D7 strain) with an IC₅₀ value of 0.0021 μM and showed low toxicity to Uppsala 87 malignant glioma (U

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC8867546 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature