Delineation of the DNA Structural Features of Eukaryotic Core Promoter Classes.

ABSTRACT: The eukaryotic transcription is orchestrated from a chunk of the DNA region stated as the core promoter. Multifarious and punctilious core promoter signals, viz., TATA-box, Inr, BREs, and Pause Button, are associated with a subset of genes and regulate their spatiotemporal expression. However, the core promoter architecture linked with these signals has not been investigated exhaustively for several species. In this study, we attempted to envisage the adaptive binding landscape of the transcription initiation machinery as a function of DNA structure. To this end, we deployed a set of k-mer based DNA structural estimates and regular expression models derived from experiments, molecular dynamic simulations, and theoretical frameworks, and high-throughout promoter data sets retr

SUBMITTER: Vanaja A 

PROVIDER: S-EPMC8867553 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature