The "Blood pressure and oxygenation targets in post resuscitation care, a randomized clinical trial": design and statistical analysis plan.

ABSTRACT:

Background

Comatose patients admitted after resuscitation from cardiac arrest have a significant risk of poor outcome due to hypoxic brain injury. While numerous studies have investigated and challenged the target temperature as the efficacious part of the guideline endorsed Targeted Temperature Management (TTM) protocols, our knowledge and how the remaining parts of the TTM are optimized remain sparse. The present randomized trial investigated two aspects of the TTM protocol: target blood pressure during the ICU stay and oxygenation during mechanical ventilation. Furthermore, the efficacy of device-based post-TTM fever management is addressed.

Methods

Investigator-initiated, dual-center, randomized clinical trial in comatose OHCA patients admitted to an intensive cardiac ca

SUBMITTER: Kjaergaard J 

PROVIDER: S-EPMC8867659 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature