5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m⁵C formation catalyzed by RNA methyltransferase.

ABSTRACT:

Objective

5-Methylcytosine (m⁵C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m⁵C has been extensively studied over the past years, the distribution and biological function of RNA m⁵C still remain to be elucidated. Here, I explored the profiles of RNA m⁵C in four mouse tissues by applying a RNA cytosine methylation data analysis tool to public mouse RNA m⁵C data.

Results

I found that the methylation rates of cytosine were the same with the averages of methylation level at single-nucleotide level. Furthermore, I gave a mathematical formula to describe the observed relationship and analyzed it deeply. The sufficient necessary condition for the given formula s

SUBMITTER: Liu J 

PROVIDER: S-EPMC8867762 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature