Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study.

ABSTRACT:

Background

Somatic depression (SD) is different from non-somatic depression (NSD), and insular subregions have been associated with somatic symptoms. However, the pattern of damage in the insular subregions in SD remains unclear. The aim of this study was to use functional connectivity (FC) analyses to explore the bilateral ventral anterior insula (vAI), bilateral dorsal anterior insula (dAI), and bilateral posterior insula (PI) brain circuits in SD patients.

Methods

The study included 28 SD patients, 30 NSD patients, and 30 matched healthy control (HC) subjects. All participants underwent 3.0 T resting state functional magnetic resonance imaging. FC analyses were used to explore synchronization between insular subregions and the whole brain in the context of depression with

SUBMITTER: Yan R 

PROVIDER: S-EPMC8867834 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature