Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.

ABSTRACT:

Background

Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson's disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dopaminergic neuron survival. The present study investigates the neuroprotective potential of MC1R against neurotoxicity induced by alpha-synuclein (αSyn), a key player in PD genetics and pathogenesis.

Methods

Nigral dopaminergic neuron toxicity induced by local overexpression of aSyn was assessed in mice that have an inactivating mutation of MC1R, overexpress its wild-type transgene, or were treated with MC1R agonists. The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in MC1R-mediated protection against αSyn was characterized in

SUBMITTER: Cai W 

PROVIDER: S-EPMC8867846 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature