How do naloxone-based interventions work to reduce overdose deaths: a realist review.

ABSTRACT:

Background

Naloxone-based interventions as part of health systems can reverse an opioid overdose. Previous systematic reviews have identified the effectiveness of naloxone; however, the role of context and mechanisms for its use has not been explored. This realist systematic review aims to identify a theory of how naloxone works based on the contexts and mechanisms that contribute to the success of the intervention for improved outcomes.

Methods

Pre-registered at PROSPERO, this realist review followed RAMESES standards of reporting. Keywords included 'naloxone' and ' opioid overdose'. All study designs were included. Data extraction using 55 relevant outputs based on realist logic produced evidence of two middle-range theories: Naloxone Bystander Intervention Theory and Skil

SUBMITTER: Miller NM 

PROVIDER: S-EPMC8867850 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature