Genomic and neuroimaging approaches to bipolar disorder.

ABSTRACT:

Background

To date, besides genome-wide association studies, a variety of other genetic analyses (e.g. polygenic risk scores, whole-exome sequencing and whole-genome sequencing) have been conducted, and a large amount of data has been gathered for investigating the involvement of common, rare and very rare types of DNA sequence variants in bipolar disorder. Also, non-invasive neuroimaging methods can be used to quantify changes in brain structure and function in patients with bipolar disorder.

Aims

To provide a comprehensive assessment of genetic findings associated with bipolar disorder, based on the evaluation of different genomic approaches and neuroimaging studies.

Method

We conducted a PubMed search of all relevant literatures from the beginning to the present, b

SUBMITTER: Oraki Kohshour M 

PROVIDER: S-EPMC8867895 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature