MiRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn(II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles.

ABSTRACT: An analytical platform for the selective miRNA-21-guided imaging of breast cancer cells and miRNA-221-guided imaging of ovarian cancer cells and the selective photodynamic therapy (PDT) of these cancer cells is introduced. The method is based on Zn(II)-protoporphyrin IX, Zn(II)-PPIX-loaded UiO-66 metal-organic framework nanoparticles, NMOFs, gated by two hairpins H_i/H_j through ligation of their phosphate residues to the vacant Zr⁴⁺-ions associated with the NMOFs. The hairpins are engineered to include the miRNA recognition sequence in the stem domain of H_i, and in the H_i and H_j, partial locked stem regions of G-quadruplex subunits. Intracellular phosphate-ions displace the hairpins, resulting in the release of the Zn(II)-PPI

SUBMITTER: Zhang P 

PROVIDER: S-EPMC8867907 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature