New thin-film adhesive for sealing full-thickness corneal incisions in rabbits.

ABSTRACT:

Purpose

To compare the repair of penetrating corneal incisions in an in vivo rabbit model using a laser-activated thin-film adhesive, sutures, or self-seal.

Setting

The University of Sydney, Camperdown, Australia.

Design

Animal studies.

Methods

Under an operating microscope, 2.0 mm penetrating incisions were created in 162 right eyes. Incisions in one group were repaired with the adhesive, the second group received a single 10-0 nylon suture, and the third group was left to self-seal. Rabbits were killed humanely at predetermined timepoints over 2 weeks, and wound healing was assessed using burst pressure and immunohistological studies. A modified McDonald-Shadduck scoring was used to assess eyes.

Results

The mean burst pressure of the adhesive group was

SUBMITTER: Tan J 

PROVIDER: S-EPMC8868184 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature