Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo.

ABSTRACT: The rising incidence of multidrug resistance in Gram-negative bacteria underlines the urgency for novel treatment options. One promising new approach is the synergistic combination of antibiotics with antimicrobial peptides. However, the use of such peptides is not straightforward; they are often sensitive to proteolytic degradation, which greatly limits their clinical potential. One approach to increase stability is to apply a hydrocarbon staple to the antimicrobial peptide, thereby fixing them in an α-helical conformation, which renders them less exposed to proteolytic activity. In this work we applied several different hydrocarbon staples to two previously described peptides shown to act on the outer membrane, L6 and L8, and tested their activity in a zebrafish embryo infection model us

SUBMITTER: Schouten GK 

PROVIDER: S-EPMC8868297 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature