Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis.

ABSTRACT: Hepatocellular carcinoma (HCC) is a health problem worldwide due to its high mortality rate, and the tumor microenvironment (TME) plays a key role in the HCC progression. The current ineffective therapies to fight the disease still warrant the development of preventive strategies. Quercetin has been shown to have different antitumor activities; however, its effect on TME components in preneoplastic lesions has not been fully investigated yet. Here, we aimed to evaluate the effect of quercetin (10 mg/kg) on TME components during the early stages of HCC progression induced in the rat. Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts m

SUBMITTER: Reyes-Avendano I 

PROVIDER: S-EPMC8868318 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature