Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca²⁺-Independent Phospholipase A₂γ in the Brain.

ABSTRACT: Mitochondrial Ca²⁺-independent phospholipase A₂γ (iPLA₂γ/PNPLA8) was previously shown to be directly activated by H₂O₂ and release free fatty acids (FAs) for FA-dependent H⁺ transport mediated by the adenine nucleotide translocase (ANT) or uncoupling protein 2 (UCP2). The resulting mild mitochondrial uncoupling and consequent partial attenuation of mitochondrial superoxide production lead to an antioxidant effect. However, the antioxidant role of iPLA₂γ in the brain is not completely understood. Here, using wild-type and iPLA₂γ-KO mice, we demonstrate the ability of tert-butylhydroperoxide (TBHP) to activate iPLA₂γ in isolated brain mitochondria, with consequent liberation of FAs and l

SUBMITTER: Pruchova P 

PROVIDER: S-EPMC8868467 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature