NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles.

ABSTRACT: Exposure to ultrafine particles (UFPs, PM_0.1) during pregnancy triggers placental oxidative stress and inflammation, similar to fine PM (PM_2.5). The Nrf2 gene encodes a redox-sensitive transcription factor that is a major regulator of antioxidant and anti-inflammatory responses. Disruption of NRF2 is known to substantially enhance PM_2.5-driven oxidant and inflammatory responses; however, specific responses to UFP exposure, especially during critical windows of susceptibility such as pregnancy, are not fully characterized; To investigate the role of NRF2 in regulating maternal antioxidant defenses and placental responses to UFP exposure, wildtype (WT) and Nrf2^-/- pregnant mice were exposed to either low dose (LD, 100 µg/m<

SUBMITTER: Behlen JC 

PROVIDER: S-EPMC8868520 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature