Quantitative Proteomic Study Unmasks Fibrinogen Pathway in Polycystic Liver Disease.

ABSTRACT: (1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism is currently unknown and the PLD treatment is limited to liver transplantation. Novel and efficient therapeutic approaches are th6us needed. In this context, the present work has a principal aim to find novel molecular pathways, as well as new therapeutic targets, involved in the hepatic cystogenesis process. (2) Methods: Quantitative proteomics based on SWATH-MS technology were performed comparing hepatic proteomes of Wild Type and mutant/polycystic livers in a polycystic kidney disease (PKD) murine model (Pkd1^cond/cond;Tam-Cre^-/+

SUBMITTER: Cordido A 

PROVIDER: S-EPMC8869147 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature