Chronic kidney disease predictors in obese adolescents.

ABSTRACT:

Background

Glomerular hyperfiltration, initiating development of obesity-related glomerulopathy, results in an enlargement of the glomeruli and unsealing of the filtration barrier. It can be followed by adaptive focal segmental glomerulosclerosis and chronic kidney disease (CKD). The aim of the study was to determine the expression pattern of lipid metabolism and selected kidney damage markers in obese adolescents and to identify potential factors which can predict CKD.

Methods

The study group consisted of 142 adolescents with a BMI z-score > 2. Sixty-two healthy and normal-weight individuals served as controls. The factors associated with the rate of glomerular filtration in obese adolescents were assessed by linear regression methods using univariate and multivariate analy

SUBMITTER: Mackowiak-Lewandowicz K 

PROVIDER: S-EPMC8869344 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature