An Immersible Microgripper for Pancreatic Islet and Organoid Research.

ABSTRACT: To improve the predictive value of in vitro experimentation, the use of 3D cell culture models, or organoids, is becoming increasingly popular. However, the current equipment of life science laboratories has been developed to deal with cell monolayers or cell suspensions. To handle 3D cell aggregates and organoids in a well-controlled manner, without causing structural damage or disturbing the function of interest, new instrumentation is needed. In particular, the precise and stable positioning in a cell bath with flow rates sufficient to characterize the kinetic responses to physiological or pharmacological stimuli can be a demanding task. Here, we present data that demonstrate that microgrippers are well suited to this task. The current version is able to work in aqueous solutions and wa

SUBMITTER: Fruh E 

PROVIDER: S-EPMC8869445 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature