Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma.

ABSTRACT: Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most patients will succumb to this disease. The low cure rate is consistent with the failure of first-line therapy, radiation and temozolomide (TMZ). Even with their therapeutic mechanism of action to incur lethal DNA lesions, tumor growth remains undeterred. Delivering additional treatments only delays the inescapable development of therapeutic tolerance and disease recurrence. The urgency of establishing lifelong tumor control needs to be re-examined with a greater focus on eliminating resistance. Early genomic and transcriptome studies suggest

SUBMITTER: Aguilar-Morante D 

PROVIDER: S-EPMC8869545 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature