A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors.

ABSTRACT:

Background

Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far.

Methods

We investigated the potential oncogenic roles of S100A7 across 33 tumors based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Moreover, a survival prognosis analysis was performed with the gene expression profiling interactive analysis (GEPIA) web server and Kaplan-Meier plotter, followed by the genetic alteration analysis of S100A7 and enrichment analysis of S100A7-related genes.

Results

S100A7 was highly expressed in most types of cancers, and remarkable associations were found between S100A7 expression and the prognosis of cancer patients

SUBMITTER: Peng G 

PROVIDER: S-EPMC8869593 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature