Ontology highlight
ABSTRACT:
SUBMITTER: Dabravolski SA
PROVIDER: S-EPMC8869605 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Dabravolski Siarhei A SA Sukhorukov Vasily N VN Kalmykov Vladislav A VA Grechko Andrey V AV Shakhpazyan Nikolay K NK Orekhov Alexander N AN
Biomedicines 20220124 2
Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent NO (nitric oxide) release, and vasodilatory effect. In addition, many KLF2-regulated genes participate in the anti-thrombotic, antioxidant, and anti-inflammatory activities, thereby preventing atherosclerosis development and progression. In this ...[more]