Plasma Proteomic Changes of Atherosclerosis after Exercise in ApoE Knockout Mice.

ABSTRACT: Atherosclerosis is the preliminary cause of coronary artery disease, one of the diseases that account for the largest number of fatal mortalities. Physical activity is an effective strategy to restrain atherosclerosis from deterioration. Evidence indicated that changes in the proteomic profile are highly associated with atherosclerosis development, but the mechanism behind exercise for atherosclerosis amelioration has not yet been investigated from a proteomics perspective. Hence, the proteomic profiles could further elucidate the systematic effects of exercise intervention on ApoE knockout atherosclerotic model and high-fat-diet intervention. In the current study, Apoe^em1Narl/Narl mice were randomly allocated into a normal diet (ND), Western diet (WD), and WD with 12-week exerc

SUBMITTER: Liao CC 

PROVIDER: S-EPMC8869651 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature