Are Neurophysiological Biomarkers Able to Discriminate Multiple Sclerosis Clinical Subtypes?

ABSTRACT: Secondary progressive multiple sclerosis (SPMS) subtype is retrospectively diagnosed, and biomarkers of the SPMS are not available. We aimed to identify possible neurophysiological markers exploring grey matter structures that could be used in clinical practice to better identify SPMS. Fifty-five people with MS and 31 healthy controls underwent a transcranial magnetic stimulation protocol to test intracortical interneuron excitability in the primary motor cortex and somatosensory temporal discrimination threshold (STDT) to test sensory function encoded in cortical and deep grey matter nuclei. A logistic regression model was used to identify a combined neurophysiological index associated with the SP subtype. We observed that short intracortical inhibition (SICI) and STDT were the only varia

SUBMITTER: Belvisi D 

PROVIDER: S-EPMC8869727 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature