PEGylation of Metal Oxide Nanoparticles Modulates Neutrophil Extracellular Trap Formation.

ABSTRACT: Novel metal oxide nanoparticle (NP) contrast agents may offer safety and functionality advantages over conventional gadolinium-based contrast agents (GBCAs) for cancer diagnosis by magnetic resonance imaging. However, little is known about the behavior of metal oxide NPs, or of their effect, upon coming into contact with the innate immune system. As neutrophils are the body's first line of defense, we sought to understand how manganese oxide and iron oxide NPs impact leukocyte functionality. Specifically, we evaluated whether contrast agents caused neutrophils to release web-like fibers of DNA known as neutrophil extracellular traps (NETs), which are known to enhance metastasis and thrombosis in cancer patients. Murine neutrophils were treated with GBCA, bare manganese oxide or iron oxide

SUBMITTER: Snoderly HT 

PROVIDER: S-EPMC8869785 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature