Validation of the INNO-LIA syphilis kit as a confirmatory assay for Treponema pallidum antibodies.

ABSTRACT: The commercially available diagnostic tests for syphilis are mostly based on the use of extracted antigens of Treponema pallidum. Pronounced cross-reactivities with other spirochete antigens are often reported. The aim of this study was to validate a novel multiparametric assay (the assay performed with the kit) INNO-LIA Syphilis for the confirmation of syphilis antibodies in a set of 840 documented human serum samples. All serum samples were previously tested at the French World Health Organization reference center for venereal diseases (Institute Alfred Fournier, Paris, France), with a consensus result provided for each sample. The study was conducted in two phases, with each phase involving a validation set (500 well-documented serum samples) and an exploratory set (340 serum samples) o

SUBMITTER: Ebel A 

PROVIDER: S-EPMC88698 | biostudies-literature | 2000 Jan

REPOSITORIES: biostudies-literature