Intrinsic and Extrinsic Factors Impacting Cancer Stemness and Tumor Progression.

ABSTRACT: Tumor heterogeneity represents an important limitation to the development of effective cancer therapies. The presence of cancer stem cells (CSCs) and their differentiation hierarchies contribute to cancer complexity and confer tumors the ability to grow, resist treatment, survive unfavorable conditions, and invade neighboring and distant tissues. A large body of research is currently focusing on understanding the properties of CSCs, including their cellular and molecular origin, as well as their biological behavior in different tumor types. In turn, this knowledge informs strategies for targeting these tumor initiating cells and related cancer stemness. Cancer stemness is modulated by the tumor microenvironment, which influences CSC function and survival. Several advanced in vitro models a

SUBMITTER: Ponomarev A 

PROVIDER: S-EPMC8869813 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature