Dataset Information

Strategies to Limit Cognitive Impairments under Sleep Restriction: Relationship to Stress Biomarkers.

ABSTRACT: Adding relaxation techniques during nap or auditory stimulation of EEG slow oscillation (SO) during nighttime sleep may limit cognitive impairments in sleep-deprived subjects, potentially through alleviating stress-releasing effects. We compared daytime sleepiness, cognitive performances, and salivary stress biomarker responses in 11 volunteers (aged 18-36) who underwent 5 days of sleep restriction (SR, 3 h per night, with 30 min of daily nap) under three successive conditions: control (SR-CT), relaxation techniques added to daily nap (SR-RT), and auditory stimulation of sleep slow oscillations (SO) during nighttime sleep (SR-NS). Test evaluation was performed at baseline (BASE), the fifth day of chronic SR (SR5), and the third and fifth days after sleep recovery (REC3, REC5, respectively). At SR5, less degradation was observed for percentage of commission errors in the executive Go-noGo inhibition task in SR-RT condition compared to SR-CT, and for sleepiness score in SR-NS condition compared both to SR-CT and SR-RT. Beneficial effects of SR-RT and SR-NS were additionally observed on these two parameters and on salivary α-amylase (sAA) at REC3 and REC5. Adding relaxation techniques to naps may help performance in inhibition response, and adding nocturnal auditory stimulation of SO sleep may benefit daytime sleepiness during sleep restriction with persistent effects during recovery. The two strategies activated the autonomic nervous system, as shown by the sAA response.

SUBMITTER: Gomez-Merino D

PROVIDER: S-EPMC8869873 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Strategies to Limit Cognitive Impairments under Sleep Restriction: Relationship to Stress Biomarkers.

Gomez-Merino Danielle D Drogou Catherine C Debellemaniere Eden E Erblang Mégane M Dorey Rodolphe R Guillard Mathias M Van Beers Pascal P Thouard Melanie M Masson Robin R Sauvet Fabien F Leger Damien D Bougard Clément C Arnal Pierrick J PJ Rabat Arnaud A Chennaoui Mounir M

Brain sciences 20220207 2

Adding relaxation techniques during nap or auditory stimulation of EEG slow oscillation (SO) during nighttime sleep may limit cognitive impairments in sleep-deprived subjects, potentially through alleviating stress-releasing effects. We compared daytime sleepiness, cognitive performances, and salivary stress biomarker responses in 11 volunteers (aged 18-36) who underwent 5 days of sleep restriction (SR, 3 h per night, with 30 min of daily nap) under three successive conditions: control (SR-CT), ...[more]

PMID: 35203992

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Project description:ObjectivesWe test the hypothesis that clinical measures of age-related cognitive, visual, and mobility impairments negatively impact older driver speed limit compliance to advance method developments that improve older patient care and screen, identify, and advise at-risk older drivers.DesignReal-world driver behaviors of older adults who had a range of cognitive, visual, and mobility abilities (measured with standardized, clinical tests) were assessed in environmental context (e.g., speed limit, traffic density, roadway type). Older driver speed limit compliance was measured in constant speed limit zones and at transition zones, where speed limits changed.SettingA naturalistic driving study of older adults living around Omaha, Nebraska.ParticipantsSeventy-seven, legally licensed, active, and typically aging older drivers (65-90 years) who had a range of cognitive and visual abilities.MeasurementsDrivers typical, daily driving was continuously monitored for 3 months using sensor instrumentation installed in their own vehicles. At study start, each participant completed a comprehensive, standardized, clinical assessment of cognitive, visual, and mobility abilities relevant to aging and driving.ResultsOlder drivers with greater cognitive impairment (P = .10) drove slower than drivers with less cognitive impairment, linking cognitive impairment to speed control. Drivers with greater visual impairment overall complied less with speed limit changes at transition zones (P = .01) and were more likely to comply with speed limit transitions when they occurred concurrently with changes in roadway features (P < .01).ConclusionResults link clinical measures of age-related cognitive and visual impairment to impaired driver safety in real-world contexts. Real-world sensor data coupled with detailed, personalized older driver profiles can inform patients, caregivers, interventions, policy, and the design of supportive in-vehicle technology for at-risk older drivers.

Dataset Information

Strategies to Limit Cognitive Impairments under Sleep Restriction: Relationship to Stress Biomarkers.

Publications

Strategies to Limit Cognitive Impairments under Sleep Restriction: Relationship to Stress Biomarkers.

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