A Contemporary Review of Molecular Therapeutic Targets for Adenoid Cystic Carcinoma.

ABSTRACT: ACC is a rare malignant tumor of the salivary glands. In this contemporary review, we explore advances in identification of targetable alterations and clinical trials testing these druggable targets. A search of relevant articles and abstracts from national meetings and three databases, including PubMed, Medline, and Web of Science, was performed. Following keyword search analysis and double peer review of abstracts to ensure appropriate fit, a total of 55 manuscripts were included in this review detailing advances in molecular targets for ACC. The most researched pathway associated with ACC is the MYB-NFIB translocation, found to lead to dysregulation of critical cellular pathways and thought to be a fundamental driver in a subset of ACC disease pathogenesis. Other notable molecular targe

SUBMITTER: Miller LE 

PROVIDER: S-EPMC8869877 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature