MicroRNA Profile Alterations in Parathyroid Carcinoma: Latest Updates and Perspectives.

ABSTRACT: Parathyroid tumors are a genetically heterogenous group with a significant variability in clinical features. Due to a lack of specific signs and symptoms and uncertain histopathological criteria, parathyroid carcinomas (PCs) are challenging to diagnose, both before and after surgery. There is a great interest in searching for accurate molecular biomarkers for early detection, disease monitoring, and clinical management. Due to improvements in molecular pathology, the latest studies have reported that PC tumorigenesis is strongly linked to the epigenetic regulation of gene expression. MicroRNA (miRNA) profiling may serve as a helpful adjunct in distinguishing parathyroid adenoma (PAd) from PC and provide further insight into regulatory pathways involved in PTH release and parathyroid tumori

SUBMITTER: Wielogorska M 

PROVIDER: S-EPMC8869975 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature