Proposal and Validation of a Novel Scoring System for Hepatocellular Carcinomas Beyond Curability Borders.

ABSTRACT: Optimal scoring system for clinical prognostic factors in patients with unresectable hepatocellular carcinoma (HCC) is currently uncertain. We aimed to develop and externally validate an easy to use tool, particularly for this population, and named it the "unresectable hepatocellular carcinoma prognostic index" (UHPI). We evaluated the data of patients with treatment-naive unresectable HCC who were diagnosed in the training center from 2010 to 2019 (n = 209). A simple prognostic model was developed by assigning points for each covariate in proportion to the beta coefficients in the Cox multivariable model. Predictive performance and distinction ability of the UHPI were further evaluated in an independent European validation cohort (n = 147) and compared with 11 other available models. A si

SUBMITTER: Demirtas CO 

PROVIDER: S-EPMC8870011 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature