Low Serum Cholinesterase Identifies Patients With Worse Outcome and Increased Mortality After TIPS.

ABSTRACT: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective treatment for portal hypertension-related complications. However, careful selection of patients is crucial. The aim of this study was to evaluate the prognostic value of serum cholinesterase (CHE) for outcomes and mortality after TIPS insertion. In this multicenter study, 389 consecutive patients with cirrhosis receiving a TIPS at Hannover Medical School, University Hospital Essen, or Medical University of Vienna were included. The Hannover cohort (n = 200) was used to initially explore the role of CHE, whereas patients from Essen and Vienna served as a validation cohort (n = 189). Median age of the patients was 58 years and median Model for End-Stage Liver Disease (MELD) score was 12. Multivariable analysis identified ME

SUBMITTER: Stockhoff L 

PROVIDER: S-EPMC8870033 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature