Prodromal Cognitive Deficits and the Risk of Subsequent Parkinson's Disease.

ABSTRACT: There is growing interest in identifying individuals who are in the prodromal phase of Parkinson's disease (PD), as these individuals are potentially suitable for inclusion in intervention trials to prevent clinically manifest PD. However, it is less clear whether-and to what extent-cognitive deficits are present in prodromal PD. A systematic query was conducted through PubMed and Embase for prospective observational cohort studies that (a) assessed cognitive performance in individuals free of manifest PD at baseline and (b) subsequently followed up participants for incident PD. We grouped the results by cognitive domain, and for domains that had been reported in at least three separate studies, we performed random-effects, inverse variance meta-analyses based on summary statistics. We ide

SUBMITTER: Speelberg DHB 

PROVIDER: S-EPMC8870093 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature