Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis.

ABSTRACT: Metastasis requires that cancer cells survive in the circulation, colonize distant organs, and grow. Despite platelets being central contributors to hemostasis, leukocyte trafficking during inflammation, and vessel stability maintenance, there is significant evidence to support their essential role in supporting metastasis through different mechanisms. In addition to their direct interaction with cancer cells, thus forming heteroaggregates such as leukocytes, platelets release molecules that are necessary to promote a disseminating phenotype in cancer cells via the induction of an epithelial-mesenchymal-like transition. Therefore, agents that affect platelet activation can potentially restrain these prometastatic mechanisms. Although the primary adhesion of platelets to cancer cells is mai

SUBMITTER: Rovati G 

PROVIDER: S-EPMC8870128 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature