Bone Marrow Stroma-Induced Transcriptome and Regulome Signatures of Multiple Myeloma.

ABSTRACT: Multiple myeloma (MM) is a hematological cancer with inevitable drug resistance. MM cells interacting with bone marrow stromal cells (BMSCs) undergo substantial changes in the transcriptome and develop de novo multi-drug resistance. As a critical component in transcriptional regulation, how the chromatin landscape is transformed in MM cells exposed to BMSCs and contributes to the transcriptional response to BMSCs remains elusive. We profiled the transcriptome and regulome for MM cells using a transwell coculture system with BMSCs. The transcriptome and regulome of MM cells from the upper transwell resembled MM cells that coexisted with BMSCs from the lower chamber but were distinctive to monoculture. BMSC-induced genes were enriched in the JAK2/STAT3 signaling pathway, unfolded protein str

SUBMITTER: Dziadowicz SA 

PROVIDER: S-EPMC8870223 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature