Histone H3 Lysine 4 and 27 Trimethylation Landscape of Human Alzheimer's Disease.

ABSTRACT:

Background

Epigenetic remodeling is emerging as a critical process for both the onset and progression of Alzheimer's disease (AD), the most common form of neurodegenerative dementia. However, it is not clear to what extent the distribution of histone modifications is involved in AD.

Methods

To investigate histone H3 modifications in AD, we compared the genome-wide distributions of H3K4me3 and H3K27me3 in entorhinal cortices from severe sporadic AD patients and from age-matched healthy individuals of both sexes.

Results

AD samples were characterized by typical average levels and distributions of the H3K4me3 and H3K27me3 signals. However, AD patients showed a lower H3K4me3 and higher H3K27me3 signal, particularly in males. Interestingly, the genomic sites found differen

SUBMITTER: Persico G 

PROVIDER: S-EPMC8870338 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature