The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific.

ABSTRACT: There is a striking sex-related difference in the prevalence of many neurodegenerative diseases, highlighting the need to consider whether treatments may exert sex-specific effects. A change in microglial activation state is a common feature of several neurodegenerative diseases and is considered to be a key factor in driving the inflammation that characterizes these conditions. Among the changes that have been described is a switch in microglial metabolism towards glycolysis which is associated with production of inflammatory mediators and reduced function. Marked sex-related differences in microglial number, phenotype and function have been described in late embryonic and early postnatal life in rodents and some reports suggest that sexual dimorphism extends into adulthood and age and, i

SUBMITTER: Mela V 

PROVIDER: S-EPMC8870377 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature