Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH.

ABSTRACT: Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are few methods for non-invasively measuring tumor extracellular pH, and none are routinely used in clinics. Responsive MRI contrast agents have been developed, and they undergo a change in MRI signal with pH. However, these signal changes are concentration-dependent, and it is difficult to accurately measure the concentration of an MRI contrast agent in vivo. PET/MRI provides a unique opportunity to overcome this concentration dependence issue by using the PET component to report on the concentration of the pH-responsive MRI agent. Herein, we synthesized PET/MRI co-agents based on the design of a pH-dependent MRI agent, and we have correl

SUBMITTER: Pollard AC 

PROVIDER: S-EPMC8870419 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature