Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.

ABSTRACT:

Background

Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in the pathogenesis of preeclampsia. Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. The aim of this study was to investigate the placental uric acid transport system, and to identify the (sub-) cellular localization of GLUT9.

Methods

Specific antibodies against GLUT9a and GLUT9b isoforms were raised, and human villous (placental) tissue was immunohistochemically stained. A systemic GLUT9 knockout (G9KO) mouse model was used to assess the placental uric acid transport capacity by measurements of uric acid serum levels in the fetal and maternal circulation.

Results

GLUT9a and GLUT9b

SUBMITTER: Luscher BP 

PROVIDER: S-EPMC8870656 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature