Myelin-Weighted Imaging Presents Reduced Apparent Myelin Water in Patients with Alzheimer's Disease.

ABSTRACT: The purpose of this study was to investigate myelin loss in both AD and mild cognitive impairment (MCI) patients with a new myelin water mapping technique within reasonable scan time and evaluate the clinical relevance of the apparent myelin water fraction (MWF) values by assessing the relationship between decreases in myelin water and the degree of memory decline or aging. Twenty-nine individuals were assigned to the cognitively normal (CN) elderly group, 32 participants were assigned to the MCI group, and 31 patients were assigned to the AD group. A 3D visualization of the short transverse relaxation time component (ViSTa)-gradient and spin-echo (GraSE) sequence was developed to map apparent MWF. Then, the MWF values were compared between the three participant groups and was evaluated th

SUBMITTER: Lim SH 

PROVIDER: S-EPMC8871299 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature