Mechanisms of distributed working memory in a large-scale network of macaque neocortex.

ABSTRACT: Neural activity underlying working memory is not a local phenomenon but distributed across multiple brain regions. To elucidate the circuit mechanism of such distributed activity, we developed an anatomically constrained computational model of large-scale macaque cortex. We found that mnemonic internal states may emerge from inter-areal reverberation, even in a regime where none of the isolated areas is capable of generating self-sustained activity. The mnemonic activity pattern along the cortical hierarchy indicates a transition in space, separating areas engaged in working memory and those which do not. A host of spatially distinct attractor states is found, potentially subserving various internal processes. The model yields testable predictions, including the idea of counterstream inhib

SUBMITTER: Mejias JF 

PROVIDER: S-EPMC8871396 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature