Role of MBL2 Polymorphisms in Sepsis and Survival: A Pilot Study and In Silico Analysis.

ABSTRACT: Sepsis is a serious infection-induced syndrome with serious ramifications, especially in intensive care units. Global concern motivated the investigation of the role of related genes' polymorphism in predicting the liability to infection, sepsis, septic shock and survival. Among these genes is the gene encoding mannose-binding lectin (MBL), with its remarkable importance in the immune system. However, the previous studies showed conflicting results and ambiguity that urged us to engage with this issue in the Egyptian population. Prediction of functional and structural impacts of single nucleotide polymorphisms (SNPs) was done using in silico methods. A prospective observational study was conducted in intensive care units; one hundred and thirty patients were followed up. Genotyping was per

SUBMITTER: Behairy MY 

PROVIDER: S-EPMC8871458 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature